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Zoloft is a serious antidepressant medication that is an SSRI, and it was introduced to the market in 1991 by Pfizer. It has been used to treat OCD, panic disorder, and social anxiety as well as its primary use of depression. It used to treat major depression in contrast to mild or moderate depression. It is the most prescribed antidepressant on the market currently in the United States. Some studies suggest it can work better than Prozac, and it has been shown to be one of the most effective antidepressants for panic disorder ever created. Some even say that it relieves premenstrual dysphoric disorder when given at doses less than the normal amount. There are some studies that suggest it gives a higher amount of serious birth effects so it is severely contraindicated for patients that are pregnant, thinking of becoming pregnant, or breastfeeding. There is some indication it may increase suicide ideation, paradoxically from its original intent.

The suicide paradox is attributed to SSRIs as a general rule, but the vast majority have their depression alleviated by the drug. Its reputation in causing sexual side effects is well known with difficult to orgasm, arousal prohibition, and the inability for women to naturally lubricate themselves. There is now a black box warning on all SSRIs including Zoloft that it may increase the risk of suicide. The results are statistically significant at 37% and 50%. A 50% increase in the odds of suicide-related events is not something to trifle with. This is a serious charge, and people should be wary before beginning the product as part of their daily regimen. Discontinuation syndrome is another symptom that can result which is basically a syndrome characterized by problems with withdrawal. 60% of the people taking Zoloft experienced withdrawal symptoms. It has some negative interactions with certain drugs.